LK700KEV is right, you have to watch what you do to it. If it is just a downloder type upgrade you have no way to monitor things, I would put an Exhaust Temp gauge on it to monitor. I have a cummins and a TST chip which doesn't change the factory fuel map, but it has a wiring harness that plugs inbetween all the injectors, cam and crank sensor, map sensor and a modified wast gate elbow. And it has an EGT sensor that monitors the tempature and will set it to go back to stock timing once it goes over the set limit, and me like nitro rtx have mine set at 1350. Now I did blow up a stock turbo, but I am not sure if it was because I was pushing 45lbs of boost out of it or it did have some burnt oil on the bearing surface. The biggest reasion turbos go bad is because if it is too hot when you shut it off the oil film left on the shaft burns to it and eventually starts to build up and lowers the bearing cartridge clearance and eventually rubs and goes bad. That is why a lot of newer tuners have a cool down timer. Mine doesn't and i think that is why mine went bad. They say you should let your egt to cool down to below 350 before you shut it off.
For reference my 03 Dodge has a 5" exhaust, south bend clutch, bigger pusher fuel pump, open air filter, TST chip, and has been making 400+hp and around 850ft-lbs since around 20,000 and I have around 180,000 on it now. With one blowed up turbo and normal ball joints, clutchs and brakes.
-Mark