I'll chime in on this one once, and then I'll move on and let everyone else argue about it.
I have spent a silly amount of time researching this subject, and have formulated my own "opinion", (they're like a-holes, don't ya know) based on what I have found, read , heard and seen.
I have read a ton of literature, studied MSDS sheets, looked up definitions of words above my head, I have talked with engine builders, factory engineers from several different product lines, and even had the opportunity to bend the ear of an oil company engineer.
It is of my "opinion" the development of fully synthetic 2 stroke oils came about for one reason and one reason only. The EPA! They were formulated as a way to help meet emission standards. They do nothing to make your engine run better or last longer. (four stoke is a completely different story!) Yes they leave less carbon behind on your power valves, but they also do not completely combust, and leave behind other chemical deposits aside from carbon. They are also less than desirable for ANY engine break in period.
Go ahead and pay $50 a gallon for synthetic coolaid, you won't harm anything. I'll stick with dead dino oil as I have done for years without issue, and I will clean my power valves once a season like I have always done.