For us it's normally a 10 hr or so drive. Leave Wednesday night after work, stop along the way, and finish the drive Thursday morning. Ride most of Thursday, then all day Fri - Monday, and drive back Tuesday, back to work Wednesday. So take 4 days off work, ride 4 1/2 to 5 days. Try to do this twice a season. My main group all has young kids and works too much, but this seems to work out right.
Also take the family up to my in-laws once a year over President's Day weekend.
We used to take longer trips in college over Christmas break, but we had very old machines so inevitably we'd spend a lot of time wrenching while we were up there too. All fun though.