I have a 2013 Eco, Crew cab, 6 1/2' box, 4x4, 331 gear. Purchased late December 2012, I have 26,000 plus miles and have had no issues with the truck. Pulling a two place with a third in the back of the truck I averaged just over 9 MPG's, A month ago pulled a 26' open tandem axel with a ranger crew and two 4 wheelers and averaged 14.5, but my average empty is only in the mid 16 mpg range. The 22 MPG advertised of course is the 2 wheel drive at an 45mph average speed.
The issue as I read it was that some of the Eco boost trucks (2012 and older) in wet conditions at mild temps while cruising for a significant period of time were having power loss issues when they would try to accelerate to pass. Ford has said the issue was with moisture build up in the intercooler and had been replacing them with a re-design unit. Did not see feed back on those that had the repair done if it corrected the problem. Did not hear any issue with it taking out turbos.